Case Series
Year : 2026 Month : October Volume : 15 Issue : 4 Page : PS01 - PS05 Full Version

Diagnostic Challenges and Management of Extrapulmonary Solitary Fibrous Tumours: A Series of Three Cases
Soumita Ghosh, Meghadri Sen, Biswanath Paul
1. Third Year PGT, Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. 2. Second Year PGT, Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. 3. Associate Professor, Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
 
Correspondence Address :
Dr. Biswanath Paul,
22/2, Umesh Mukherjee Road, P.O- Belgharia-700056, Kolkata,
West Bengal, India.
E-mail: paul.biswanath1@gmail.com
 
ABSTRACT
: Solitary Fibrous Tumours (SFT)s are rare soft-tissue tumours of mesenchymal origin, which are even more rare in the head and neck region. They are typically benign in nature but in rare circumstances may show transformation into malignancy. Histologically, they show a well-encapsulated biphasic lesion, having hypo- and hyper-cellular with cells with bland spindle shaped nuclei, arranged in fascicles, in a stroma comprised of ropey collagen, having haemangiopericytoma like patulous vasculature. Occasionally, the lesion may show cystic spaces. Usually, these tumours do not show necrosis, atypia or abnormal mitoses. SFTs are typically positive for STAT6, CD34, BCL2 and CD99. Complete surgical excision is the treatment of choice, but often the tumour shows recurrence. This case series presents three cases. The first case is a 32-year-old male presenting with a painless firm mass, in right submandibular region since last one year. The second case is a 41-year-old male presenting with a firm swelling over the right-side of his nose, with tenderness in the area, associated with epistaxis from his right nostril and difficulty in breathing. He was previously operated for the same in 2018, but few months after every surgery the symptoms had recurred, and he had undergone a total of three operative procedures and one session of radiotherapy till 2024. The third case is a 62-year-old male presenting with a slow growing, non tender swelling over the calf of his left leg for one year. All the cases have been managed with total surgical resection, and microscopically showed the above-mentioned histologic features of SFTs. On immunohistochemistry, they showed positivity for STAT6, BCL2, CD34 and CD99. Based on the histological and Immunohistochemistry (IHC) findings, the tumours were diagnosed to be SFT. This series is focused on the extrapulmonary unusual sites of presentation of SFT, because early diagnosis and treatment is always helpful to the patients.
Keywords : Biphasic, Mesenchymal origin, Submandibular region, Well-encapsulated
DOI and Others : DOI: 10.7860/NJLM/2026/88580.2998 Date of Submission: Mar 05, 2025 Date of Peer Review: Apr 17, 2026 Date of Acceptance: Jul 07, 2026 Date of Publishing: Oct 01, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? NA (retrospective data from records was used) • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Mar 06, 2026 • Manual Googling: Jul 02, 2026 • iThenticate Software: Jul 06, 2026 (1%) ETYMOLOGY: Author Origin EMENDATIONS: 7
 
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