Original article / research
Year : 2026 Month : January Volume : 15 Issue : 1 Page : MO20 - MO25 Full Version

Mupirocin Resistance among Methicillin Resistant and Sensitive Staphylococcus aureus from Skin and Soft Tissue Infections: A Cross-sectional Study at a Tertiary Care Hospital in Southern Haryana, India
Pooja Singla, Dimpi Bhankhur, Pratibha Mane, Jyoti Sangwan Lathwal
1. Professor, Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, Haryana, India. 2. Assistant Professor, Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, Haryana, India. 3. Professor, Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, Haryana, India. 4. Professor, Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, Haryana, India.
 
Correspondence Address :
Dr. Dimpi Bhankhur,
Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical
College, Nalhar, Nuh-122107, Haryana, India.
E-mail: dimpibhankhur@gmail.com
 
ABSTRACT
: Introduction: Staphylococcus aureus is a bacterium associated with the majority of Skin and Soft Tissue Infections (SSTIs). It possesses a wide range of virulence factors and an inherent ability to acquire resistance mechanisms. The incidence of drug resistance in S. aureus has increased significantly. Mupirocin is a key treatment option for decolonisation of carriers. However, rising resistance to mupirocin poses a major challenge in the decolonisation of carriers and in preventing transmission of infection to susceptible individuals.

Aim: To determine the mupirocin susceptibility pattern in Staphylococcus aureus isolated from SSTIs at a tertiary care hospital.

Materials and Methods: The present study was an observational, cross-sectional study conducted over a period of two years in the Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College (SHKMGMC), Nalhar, Haryana, India. Out of a total of 2,156 pus samples, 160 isolates of Staphylococcus aureus were obtained and subjected to antimicrobial susceptibility testing using the disc diffusion method.

Results: Of the 160 Staphylococcus aureus isolates, 31.87% were methicillin-resistant S. Aureus (MRSA). Overall mupirocin resistance was observed in 15.6% of isolates. High-level mupirocin resistance and low-level mupirocin resistance were noted in 11.87% and 3.75% of isolates, respectively. Inducible clindamycin resistance was detected in 17.5% of isolates. Co-resistance to mupirocin and MRSA was observed in 10.6% of cases, while combined resistance to mupirocin, MRSA, and inducible clindamycin was seen in 1.9% of isolates.

Conclusion: The proportion of mupirocin resistance was higher among MRSA isolates. A significant association was observed between high-level mupirocin resistance and MRSA.
Keywords : Antibiotics, Infection control, Pus
DOI and Others : DOI: 10.7860/NJLM/2026/85246.2957 Date of Submission: Nov 05, 2025 Date of Peer Review: Nov 14, 2025 Date of Acceptance: Dec 26, 2025 Date of Publishing: Jan 01, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Nov 06, 2025 • Manual Googling: Dec 11, 2025 • iThenticate Software: Dec 19, 2025 (8%) ETYMOLOGY: Author Origin EMENDATIONS: 7
 
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