Case Series
Year : 2026 Month : April Volume : 15 Issue : 2 Page : PS01 - PS04 Full Version

Diverse Presentations of Angiomyxomas: A Series of Three Cases
Kundhavai Chandrasekaran, Vijayashree Raghavan, NR Rajesh Kanna
1. Assistant Professor, Department of Pathology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India. 2. Professor and Head, Department of Pathology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India. 3. Professor, Department of Pathology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
 
Correspondence Address :
Dr. NR Rajesh Kanna,
Chettinad Hospital and Research Institute, Chettinad Academy of Research and
Education, Kelambakkam-603103, Tamil Nadu, India.
E-mail: rajeshthuva@gmail.com
 
ABSTRACT
: Angiomyxomas are uncommon mesenchymal tumours that typically arise in the vulvovaginal and pelvic regions of women and only rarely in men. Their indolent growth and resemblance to other soft-tissue lesions often complicate clinical diagnosis. We describe three cases that demonstrate both classical and unusual patterns of presentation. Two young women, aged 22 and 35 years, presented with slowly enlarging vulvar masses. Both lesions were ill-defined, gelatinous, and composed microscopically of stellate and spindle cells within a loose myxoid stroma containing numerous thick-walled vessels. Immunohistochemistry revealed desmin and Oestrogen Receptor (ER) positivity with a low proliferative index, supporting the diagnosis of angiomyxoma. The third case involved a 49-year-old man who presented with acute intestinal obstruction due to ileal intussusception. The resected lesion showed similar morphologic features with desmin, Smooth Muscle Antigen (SMA), and Cluster of Differentiation 34 (CD34) positivity, and was distinguished from inflammatory fibroid polyp by the absence of onion-skin perivascular arrangement. All patients underwent complete excision and remained disease-free on follow-up. This series highlights the diagnostic role of histology and immunohistochemistry, underscores the importance of distinguishing angiomyxoma from histological mimics, and broadens the clinical spectrum by documenting a rare intestinal case.
Keywords : Desmin, Mesenchymal tumour, Spindle cells, Vulvovaginal
DOI and Others : DOI: 10.7860/NJLM/2026/78147.2962 Date of Submission: Jan 19, 2025 Date of Peer Review: Mar 10, 2025 Date of Acceptance: Aug 28, 2025 Date of Publishing: Apr 01, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jan 20, 2025 • Manual Googling: Aug 18, 2025 • iThenticate Software: Aug 27, 2025 (3%) ETYMOLOGY: Author Origin EMENDATIONS: 7
 
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