Case Series
Year : 2025 Month : October Volume : 14 Issue : 4 Page : PS01 - PS04 Full Version

Distant Soft-tissue Metastasis of Follicular Thyroid Carcinoma: A Series of Three Cases
Rituparna Das, Sayantan Jana, Biswanath Paul, Anurima Nayak
1. Third Year Postgraduate, Department of Pathology, IPGME&R, Kolkata, West Bengal, India. 2. Assistant Professor, Department of Pathology, Mednapore Medical Collage, Kolkata, West Bengal, India. 3. Associate Professor, Department of Pathology, IPGME&R, Kolkata, West Bengal, India. 4. Third Year Postgraduate, Department of Pathology, IPGME&R, Kolkata, West Bengal, India.
 
Correspondence Address :
Biswanath Paul,
22/2, Umesh Mukherjee Road, P.O- Belgharia, Kolkata-700056, West Bengal, India.
E-mail: paul.biswanath1@gmail.com
 
ABSTRACT
: Follicular Thyroid Carcinoma (FTC) accounts for 25-40% of thyroid cancers and is more common in women. The peak incidence is between 40 and 60 years of age. The extent of invasion and stage at presentation are the main prognostic factors of FTC. Invasive carcinoma often presents with systemic metastases to the lungs, skeleton, and brain, with other less common sites including the breast, muscle, and skin. Soft-tissue metastasis is a rare presentation; only limited data are available in the literature. Here, we report three adult females with soft-tissue metastasis of FTC in the gluteal, facial, and inguinal regions. All cases had a prior diagnosis of FTC and had undergone thyroidectomy. During postoperative evaluation, they presented with soft-tissue swelling. All cases presented six months to one year after successful thyroidectomy. In two cases, metastasis occurred in distant soft-tissue sites such as the thigh and gluteal region, whereas in one case the face (a closer region) was involved. The cases were provisionally diagnosed by Fine Needle Aspiration Cytology (FNAC), followed by tru-cut biopsy and Histopathological Examination (HPE). The diagnosis was confirmed by immunohistochemical staining. As metastasis of FTC to soft-tissue is unusual, postoperative follow-up of all FTC patients is mandatory for early detection and treatment.
Keywords : Fine needle aspiration cytology, Immunohistochemical stain, Post-thyroidectomy follow-up, Prognostic factor, Thyroidectomy, Tru-cut biopsy
DOI and Others : DOI: 10.7860/NJLM/2025/81080.2932 Date of Submission: Jun 03, 2025 Date of Peer Review: Jul 03, 2025 Date of Acceptance: Aug 09, 2025 Date of Publishing: Oct 01, 2025 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jun 13, 2025 • Manual Googling: Jul 19, 2025 • iThenticate Software: Aug 08, 2025 (5%) ETYMOLOGY: Author Origin EMENDATIONS: 6
 
TABLES AND FIGURES