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| Year:
2026 |
Month:
January
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Volume:
15 |
Issue:
1 |
Page:
MO20 - MO25 |
Mupirocin Resistance among Methicillin Resistant and Sensitive Staphylococcus aureus from Skin and Soft Tissue Infections: A Cross-sectional Study at a Tertiary Care Hospital in Southern Haryana, India
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Correspondence
Pooja Singla, Dimpi Bhankhur, Pratibha Mane, Jyoti Sangwan Lathwal,
Dr. Dimpi Bhankhur,
Assistant Professor, Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh-122107, Haryana, India.
E-mail: dimpibhankhur@gmail.com :
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Introduction: Staphylococcus aureus is a bacterium associated with the majority of Skin and Soft Tissue Infections (SSTIs). It possesses a wide range of virulence factors and an inherent ability to acquire resistance mechanisms. The incidence of drug resistance in S. aureus has increased significantly. Mupirocin is a key treatment option for decolonisation of carriers. However, rising resistance to mupirocin poses a major challenge in the decolonisation of carriers and in preventing transmission of infection to susceptible individuals.
Aim: To determine the mupirocin susceptibility pattern in Staphylococcus aureus isolated from SSTIs at a tertiary care hospital.
Materials and Methods: The present study was an observational, cross-sectional study conducted over a period of two years in the Department of Microbiology, Shaheed Hasan Khan Mewati Government Medical College (SHKMGMC), Nalhar, Haryana, India. Out of a total of 2,156 pus samples, 160 isolates of Staphylococcus aureus were obtained and subjected to antimicrobial susceptibility testing using the disc diffusion method.
Results: Of the 160 Staphylococcus aureus isolates, 31.87% were methicillin-resistant S. aureus (MRSA). Overall mupirocin resistance was observed in 15.6% of isolates. High-level mupirocin resistance and low-level mupirocin resistance were noted in 11.87% and 3.75% of isolates, respectively. Inducible clindamycin resistance was detected in 17.5% of isolates. Co-resistance to mupirocin and MRSA was observed in 10.6% of cases, while combined resistance to mupirocin, MRSA, and inducible clindamycin was seen in 1.9% of isolates.
Conclusion: The proportion of mupirocin resistance was higher among MRSA isolates. A significant association was observed between high-level mupirocin resistance and MRSA.
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