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| Year:
2026 |
Month:
April
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Volume:
15 |
Issue:
2 |
Page:
PS01 - PS04 |
Diverse Presentations of Angiomyxomas: A Series of Three Cases
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Correspondence
Kundhavai Chandrasekaran, Vijayashree Raghavan, NR Rajesh Kanna,
Dr. NR Rajesh Kanna,
Chettinad Hospital and Research Institute, Chettinad Academy of Research and
Education, Kelambakkam-603103, Tamil Nadu, India.
E-mail: rajeshthuva@gmail.com :
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Angiomyxomas are uncommon mesenchymal tumours that typically arise in the vulvovaginal and pelvic regions of women and only rarely in men. Their indolent growth and resemblance to other soft-tissue lesions often complicate clinical diagnosis. We describe three cases that demonstrate both classical and unusual patterns of presentation. Two young women, aged 22 and 35 years, presented with slowly enlarging vulvar masses. Both lesions were ill-defined, gelatinous, and composed microscopically of stellate and spindle cells within a loose myxoid stroma containing numerous thick-walled vessels. Immunohistochemistry revealed desmin and Oestrogen Receptor (ER) positivity with a low proliferative index, supporting the diagnosis of angiomyxoma. The third case involved a 49-year-old man who presented with acute intestinal obstruction due to ileal intussusception. The resected lesion showed similar morphologic features with desmin, Smooth Muscle Antigen (SMA), and Cluster of Differentiation 34 (CD34) positivity, and was distinguished from inflammatory fibroid polyp by the absence of onion-skin perivascular arrangement. All patients underwent complete excision and remained disease-free on follow-up. This series highlights the diagnostic role of histology and immunohistochemistry, underscores the importance of distinguishing angiomyxoma from histological mimics, and broadens the clinical spectrum by documenting a rare intestinal case.
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