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| Year:
2016 |
Month:
January
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Volume:
5 |
Issue:
1 |
Page:
26 - 29 |
Carcinosarcoma of Breast with Hormone Receptor and Her 2/neu Positivity
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Correspondence
Deepti Agarwal, Vijay Malik, Ruchi Agarwal, M.K. Garg, Shilpapa Garg,
Dr. Deepti Agarwal,
Associate Professor, Department of Pathology, BPS Govt.
Medical College for Women, Khanpur Kalan, Sonipat,
Haryana, India.
E-mail: deeptiagarwal@rocketmail.com :
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Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year old female presented to surgical outpatient with a fungating mass in the right breast where cytological analysis from the affected areas revealed spindle cells of malignant potential. A modified radical mastectomy was performed and following histopathological examination of the excised tissue, a final diagnosis of carcinosarcoma of breast was concluded. Immunological staining done showed a negative staining for PR and positive staining for ER, Her -2/neu and CK receptors, as against the conventional triple negative staining pattern. Along with a rare staining pattern of this rare tumor reported in literature, this case merits presentation owing to its diagnostic and therapeutic challenges.
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