N J L M

 
Subscribe Via RSS
  • Home
  • About
    Salient Features Bibliographic Information Abstracting and Indexing Specialties Covered Publisher Journal Policy
  • Issues
    Current Issue Online Ahead of Print Archive Forthcoming issue
  • Editorial
    Editorial Statements Editorial-PeerReview Process Editorial Board Publication Ethics & Malpractice Join us
  • Authors
    Submit an Article Manuscript Instructions Manuscript Assistance Publication Charges Paid Services Early Online Publication Service
  • Reviewers
    Apply as Reviewer Reviewers Acknowledgment
  • Search
    Simple Search Advanced Search
  • Member
    Register Login
  • Contact
  • Subscription
Original article / research
Year: 2018 Month: October Volume: 7 Issue: 4 Page: PO28 - PO33

Correlation of Histology of Vesiculobullous Disorders With Immunofluorescence: A Study at A Tertiary Care Centre

 
Correspondence Sarwat Fatma, Swetha Narla, Sheba Jacob, N Geetha,
Dr. Swetha Narla,
320 Anna Salai, Chennai-600035, Tamil Nadu, India.
E-mail: drswetha.gmc2k2@gmail.com
:
Introduction: Vesiculobullous disorders present with varied clinical manifestations. Vesicles and bullae are fluid filled cavities present within or beneath the epidermis. They are autoimmune blistering disorders in which autoantibodies are directed against target antigens present in the epidermis and dermoepidermal junction.

Aim: To study and analyse the clinical, histopathological and immunofluorescence findings in bullous lesions of the skin and to determine the contribution of immunofluorescence in diagnosing these conditions when there is a histological overlap.

Materials and Methods: A total of 50 cases were selected in a two years span. Punch biopsy specimens of the skin taken from early lesions, sent for histopathological examination and Direct Immunofluorescence (DIF), were processed routinely. The light microscopic and immunofluorescence stained slides were studied and correlated with the clinical findings.

Results: Pemphigus vulgaris was the most common vesiculobullous disorder (36%) followed by bullous pemphigoid (28%), pemphigus foliaceus (10%),hailey-hailey disease (8%), dermatitis herpetiformis (8%) and others (10%).

Conclusion: The present study concludes that all the patients of vesiculobullous disorder may not present clinically with classical morphological features. In such conditions where clinical diagnosis is a problem, biopsy from the lesion helps in arriving at the final diagnosis. In cases where histopathological findings are not typical, DIF helps to diagnose the disease which shows typical pattern of immune deposition at the appropriate site. So, a separate specimen should be submitted for DIF. In order to make a final diagnosis, it is important to correlate the clinical details, history of prior treatment, histomorphological and DIF findings.
 
[ FULL TEXT ]   |   [ ]
 
Print
  • Article Utilities

    • Readers Comments (0)
    • Article in PDF
    • Citation Manager
    • Article Statistics
    • Link to PUBMED
    • Print this Article
    • Send to a Friend
    • Go To Issues

      • Current Issue
      • Past Issues
  • Search Articles

    • Simple Search
    • Advance Search
  • Authors Facilities

    • Extensive Author Support
    • Submit Manuscript
    • ONLINE First Facility
    • NJLM Pre Publishing
  • Quick Links

    • REVIEWER
    • ACCESS STATISTICS
  • Users

    • Register
    • Log in
  • Pages

    • About
    • Issues
    • Editorials
    • Authors
    • Reviewers
    • Search
    • Contacts
  • Issues Archives

  • Affiliated Websites

    • JCDR Prepublishing
    • Neonatal Database Home
    • JCDR Neonatal Database download center