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| Year:
2016 |
Month:
July
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Volume:
5 |
Issue:
3 |
Page:
- |
Apolipoprotein B / Apolipoprotein A-I
Ratio a better Diagnostic Marker
of Coronary Heart Disease than Conventional LDL/HDL Ratio
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Correspondence
Jayesh S.Prajapati, Jagjeet K.Deshmukh, Krutika H. Patel, Komal H.Shah
H
asit J. Joshi, Ranajeet More, Sibasis S. Sahoo,
Dr. Jayesh S. Prajapati,
U N Mehta Institute of Cardiology and Research Center (UNMICRC) B. J. Medical College and Civil Campus, Asarwa, Ahmedabad-380016, Gujarat, India.
E-mail: drjsprajapati@yahoo.co.in :
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Introduction: Apolipoprotein B (Apo B) and apolipoprotein A-I (Apo-I) are cholesterol transporters playing an important role in lipid metabolism. Apo B and A-I represent the total atherogenic and non-atherogenic particles respectively. Hence, their ratio – Apo B/A-I has been strongly associated with various cardiovascular events.
Aim: To compare the diagnostic efficacy of apolipoproteins with conventional lipids for coronary heart disease.
Materials and Methods: There were 295 individuals with or without coronary heart disease were enrolled in the study. The demographic details along with clinical investigations of serum lipid parameters, Apo B and Apo A-I levels were obtained and recorded.
Study Design: It was a single centre, prospective observational study of 295 individuals of both the genders (235 males and 60 females) with or without coronary artery disease. Statistical Analysis: A comparison of parametric values between two groups was performed using student’s t-test. Non-parametric analysis of the continuous data was performed using Mann-Whitney U test. Significance was taken as two tailed p<0.05.
Results: In study population, 221(74.92%) had coronary heart disease (CHD) and 74(25.08%) were normal. Statistically significant differences were found in the levels of apo B/apo A-I ratio (p=0.009), and Apo A-I (p=0.001) between two groups. The other lipid parameters and ratios such as cholesterol, triglyceride, HDL-C, LDL-C, nonHDL-C cholesterol, VLDL, Total lipid, Apo-B, LDL-C/HDL-C and TC/HDL-C were not found to be significant.
Conclusion: The present study shows that Apo B/A-I possesses superior diagnostic efficacy for coronary heart disease as compared to conventional lipid parameters and could be effectively used in clinical practice.
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