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| Year:
2013 |
Month:
August
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Volume:
2 |
Issue:
2 |
Page:
1 - 6 |
Study of Paraoxonase 1 (PON1) Activity as an Independent Risk Factor in Coronary Artery Disease
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Correspondence
Sangita M. Patil, Mangesh P. Banker,Ramchandra k. Padalkar,ABhijit P.Pathak, Shital Ghodke,Anjali S. Phatake, Sonali S. Bhagat,Rahul A.Ghone,
Ms. Sangita M. Patil,
Assistant Professor, Department of Biochemistry,
PDVVPF’s Medical College, Ahmednagar, (M.S.), India.
Email: vsrk_om@rediffmail.com
Ph: 9765653919 :
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Background:Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Human serum paraoxonase-1 is a high density lipoprotein bound enzyme exhibiting antiatherogenic properties.
Aim:The aim of present study was planned to evaluate the serum paraoxonase-1 activity and lipid profile with coronary artery disease in addition to investigate the relationship between serum HDL-C and PON1 levels in patients with Coronary Artery Disease.
Material and Methods:In the present case-control study 142 with coronary artery disease (age range 26 to 72) and 115 age and sex matched healthy controls were recruited. Serum paraoxonase activities were measured spectrophotometrically by using phenyl acetate as substrate by kinetic assay while lipid profile was analysed by enzymatic method by cholesterol oxidase peroxidase (CHOD-PAP) method of total cholesterol and high density lipoprotein cholesterol and glycerol 3- phosphate oxidase (GPO-PAP) method of triglyceride. Values were expressed as mean ± standard deviation and data from patients and controls were compared by using student t-test.
Results:Significantly lower serum paraoxonase 1 activity (p<0.001) along with the lower high density lipoprotein cholesterol (p<0.001) and higher low density lipoprotein cholesterol, triglycerides and very low density lipoprotein cholesterol were observed in coronary artery disease patients as compared to healthy controls. The linear correlation in between serum paraoxonase-1 activity and HDL-C levels was found in the coronary artery disease like Myocardial infarction(r=0.208), stable angina (r = -0.051) and unstable angina (r = - 0.103) and in the controls (r=0.102).
Conclusion:The low serum paraoxonase 1 activity may be an independent risk factor for coronary artery disease furthermore it can be used as primitive marker of progression of atherosclerosis and coronary artery disease.
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